Major Compound in Grape Skins, Resveratrol, Found to Attack Cancer Cells in the Lungs and the Prostate

According to the University of Virginia Health System press release, the National Cancer Institute and the Paul Mellon Prostate Cancer Institute sponsored Professor Marty Mayo’s research on resveratrol with several grants and has reported that resveratrol has amazing health benefits and is a powerful agent in the war against cancer cells in both the prostate and the lungs.

Marty Mayo, professor of biochemistry and molecular genetics, and his University of Virginia research team analyzed the compound — called resveratrol which is commonly found in grape skins and therefore red wine — for over a year and a half. Mayo said that they knew resveratrol destroyed cancer cells, but they wanted to know why and how it did it.

“What resveratrol does is it removes these marks, or particular sites, in the protein, and these marks are required for transcription, [which is] the process of making gene products that cancer cells like,” Mayo said. “[This] slows the process that cancer cells need to survive and they eventually die.”

Mayo said resveratrol is found in red wine, but that resveratrol supplements are also available. They should also be an excellent cancer preventative.

Mayo’s post-doctoral student, Fan Yeung, published the findings in the online May 20 edition of the Journal of the European Molecular Biology Organization.

Resveratrol attacks the protein, NF-kB, which is “responsible for upregulating gene products that control cell survival,” according to Yeung’s article.

“Nuclear factor-kappa B (NF-kB) controls the expression of gene products that affect important cellular processes, such as adhesion, cell cycle, angiogenesis, and apoptosis,” the study stated.

When asked which cancers resveratrol worked best on, Fan Yeung responded by saying, “We tested lung cancer and prostrate cancer. Resveratrol worked on cancer cells in the prostate, but on lung cancer cells pretty well, too.”

Other Health Benefits Provided by Resveratrol

Resveratrol also has other health benefits. Epidemiological studies have shown that consumption of wine reduces the risk of coronary heart disease, but many people cannot drink alcohol and wine is an expensive drink.

Resveratrol and quercetin, two polyphenolic compounds found in grapes and wine, have been shown to markedly reduce the risk of coronary heart disease. Both compounds exert several biological properties which are associated with cardioprotection. Both of these are now available in supplement form.

In cell culture experiments, resveratrol prevented influenza from replicating.

According to a U.S. study reported in the New York Times and the Washington Post, out of several substances studied, resveratrol is the only one that caused the human body to produce what researchers called “an anti-aging enzyme.”

Writing in an early online edition of Nature (14 July 2004; doi:10.1038/nature 02789), David Sinclair from Harvard Medical School and colleagues at the University of Connecticut and Brown University in Rhode Island reported that resveratrol activated proteins called sirtuins in fruitflies and worms, extending their lifespan without reducing fertility.

Resveratrol also reduces the body’s ability to make fat cells and increases the body’s ability to use fat for energy, helping to keep the body leaner.

A different group of researchers reported that resveratrol significantly increased the activity level of a gene called SIRT1 in mice. Also found in humans, this gene has essentially the same function as SIR2 (the one studied by Sinclair in the above mentioned study) and the same reaction to stimulus by resveratrol. SIRT1 was found to increase the use of fat and reduces the formation of new fat cells.

Note: Like Co-Enzyme Q-10, researchers are continuing to find more and more health benefits that this natural substance, resveratrol, provides. And why are doctors not pushing these two substances? Because the drug industry does not report these studies to them, because it cannot patent natural substances — only those made in a lab. Therefore, there is no money in it for the greedy, merciless medical industry, and because doctors can’t use them — as they do drugs — to keep patients under their palms, they certainly aren’t going to recommend them either, even if they knew about them, and most don’t. People must understand that 95 percent of practicing doctors receive all their information from the medical industry, and they do not, I repeat — do not!! — report studies such as the ones mentioned above to doctors. This is a know fact!

But clearly, the studies are out there, and they are conclusive: the two most powerful natural healing substances ever discovered are resveratrol and Co-Q10.

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